What it is
Arginine alpha-ketoglutarate, usually written AAKG or Arginine AKG, is arginine bonded to alpha-ketoglutarate, a compound from the cell's energy cycle. The 2:1 ratio means two parts arginine to one part AKG.
What it does in Memoclear
The idea behind AKG is timing. Plain arginine is absorbed and cleared fast. Binding it to AKG is meant to slow that down, so nitric oxide support continues later into the day instead of peaking and fading. AKG itself also feeds into the energy cycle that brain cells depend on. In Memoclear it sits alongside base arginine so the formula has a fast component and a slower one.
Where it comes from in food
Arginine comes from the same foods as above; alpha-ketoglutarate is made inside the body's energy cycle.
What the research says
AAKG has been studied mostly in sports nutrition. Some trials show it raises blood arginine and has small effects on strength or blood flow; others show little difference from plain arginine. Research on AAKG specifically for memory or focus is thin. The blood-flow mechanism is shared with arginine.
Who should be careful
Same cautions as L-Arginine: talk to your doctor if you take blood pressure medicine, nitrates or erectile dysfunction medicine, or if you have had a recent heart attack. Do not stack it with other arginine or AAKG products.
Where it sits in the formula
L-Arginine AKG 2:1 Extract works alongside the other five ingredients: L-Arginine (base), L-Citrulline HCL, L-Citrulline Malate, Niacin (Vitamin B3), Beta-Alanine. Together they cover blood flow, cell energy and neuron protection in one daily capsule.
Further reading
Arginine alpha-ketoglutarate, PubMed. This research is on the ingredient, not on the finished Memoclear product.